Article
The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Heras Begoña, Totsika Makrina, Peters Kate M, Paxman Jason J, Gee Christine L, Jarrott Russell J, Perugini Matthew A, Whitten Andrew E, Schembri Mark A
Abstract excerpt
Aggregation and biofilm formation are critical mechanisms for bacterial resistance to host immune factors and antibiotics. Autotransporter (AT) proteins, which represent the largest group of outer-membrane and secreted proteins in Gram-negative bacteria, contribute significantly to these phenotypes. Despite their abundance and role in bacterial pathogenesis, most AT proteins have not been structurally...
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