Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2015

Lombardi Anne J, Hoskins Elizabeth E, Foglesong Grant D, Wikenheiser-Brokamp Kathryn A, Wiesmüller Lisa, Hanenberg Helmut, Andreassen Paul R, Jacobs Allison J, Olson Susan B, Keeble Winifred W, Hays Laura E, Wells Susanne I

Abstract excerpt

PURPOSE: Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with Fanconi anemia are predisposed to formation of head and neck squamous cell carcinoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA End-Joining Repair
Share to Fanconi Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Heterografts

Share to Ku Autoantigen

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Poly(ADP-ribose) Polymerases

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 25609062
DOI: 10.1158/1078-0432.CCR-14-2616
PMCID: PMC4401632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25609062-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.PMID 25609062Read ↗

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resourceSemantic proximity Read ↗

Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resourceSemantic proximity Read ↗

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.Semantic proximity Read ↗

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.Semantic proximity Read ↗

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation responseSemantic proximity Read ↗

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Semantic proximity Read ↗

Fanconi anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatments.Semantic proximity Read ↗

Generation and Molecular Characterization of Head and Neck Squamous Cell Lines of Fanconi Anemia PatientsSemantic proximity Read ↗

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patientsSemantic proximity Read ↗

Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cellsSemantic proximity Read ↗

Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.Semantic proximity Read ↗

Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.