Article
Antigenic composition and immunoreactivity differences between HEV recombinant capsid proteins generated from different genotypes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2015
Behloul Nouredine, Wen Jiyue, Dai Xing, Dong Chen, Meng Jihong
Abstract excerpt
Appreciable variability has been observed in hepatitis E virus (HEV) serological diagnostics. Four recombinant proteins (p166s) were generated from position 452 to 617 aa of ORF2 of different HEV genotypes and used in an indirect ELISA to detect anti-HEV IgMs and IgGs in serially diluted sera of patients infected with different HEV genotypes (genotype 1, n=15; genotype 3, n=12; genotype 4, n=17). To evaluate the...
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