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Hepatitis E virus (HEV) open reading frame 2: Role in pathogenesis and diagnosis in HEV infections

9 Oct 2022

Abstract excerpt

Hepatitis E virus (HEV) infection occurs worldwide. The HEV genome includes three to four open reading frames (ORF1-4). ORF1 proteins are essential for viral replication, while the ORF3 protein is an ion channel involved in the exit of HEV from the infected cells. ORF2 proteins form the viral capsid required for HEV invasion and assembly. They also suppress interferon production and inhibit antibody-mediated...

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PMID: 36209386
DOI: 10.1002/rmv.2401

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