Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigenic heterogeneity of the NS3 proteins in hepatitis C virus genotypes 1 and 6.

Intervirology - 1 Feb 2011

Qiao Weizhen, Xie Ping, Cai Bing, Li Lingling

Abstract excerpt

OBJECTIVE: To investigate the effect of sequence variability between different genotypes of hepatitis C virus (HCV) on the antigenic properties of the NS3 proteins, and to evaluate the significance of the proteins in the serological diagnosis. METHODS: The recombinant expression plasmids of pET/NS3-1 and pET/NS3-6 were constructed with the NS3 region fragments from HCV genotypes 1 and 6, respectively. The...

Topics

Antigens, Viral
Enzyme-Linked Immunosorbent Assay
Genetic Variation
Genotype
Hepacivirus
Hepatitis C
Humans
Serologic Tests
Serotyping
Viral Nonstructural Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20829600
DOI: 10.1159/000316312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigenic heterogeneity of the NS3 proteins in hepatitis C virus genotypes 1 and 6.PMID 20829600Read ↗

Gene expression of NS5a strong antigenic regions of hepatitis C virus in E.coli and detection of their antigenicity.Semantic proximity Read ↗

Antigenic composition and immunoreactivity differences between HEV recombinant capsid proteins generated from different genotypes.Semantic proximity Read ↗

Hepatitis C virus nonstructural 3 protein: recombinant NS3 protein of the Thai isolates as an antigen in a diagnostic assay.Semantic proximity Read ↗

[Impact of the heterogenicity of amino acid sequence on the immunoreactivity of an antigenic epitopic complex localized within amino acids 1192-1456 of protein NS3 protein of hepatitis C virus].Semantic proximity Read ↗

Expression of the full-length HCV core subgenome from HCV gentoype-1a and genotype-3a and evaluation of the antigenicity of translational products.Semantic proximity Read ↗

Expression of Hepatitis C Virus Core and E2 antigenic recombinant proteins and their use for development of diagnostic assays.Semantic proximity Read ↗

Sero-reactivity to three distinct regions within the hepatitis C virus alternative reading frame protein (ARFP/core+1) in patients with chronic HCV genotype-3 infection.Semantic proximity Read ↗

Antigenic variation of core, NS3, and NS5 proteins among genotypes of hepatitis C virus.Semantic proximity Read ↗

Serological response to infection with different isolates of hepatitis C virus.Semantic proximity Read ↗

Identification of immunogenic regions within the alternative reading frame protein of hepatitis C virus (genotype 3).Semantic proximity Read ↗

The relationship between virological characteristics of hepatitis C virus (HCV) and reactivity to the regional specific proteins of HCV.Semantic proximity Read ↗

A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.