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Article

Genetic substructure and host-specific natural selection trend across vaccine-candidate ORF-2 capsid protein of hepatitis-E virus.

Journal of viral hepatitis - 1 Sept 2024

Khan Nasir, Kakakhel Sehrish, Malik Abdul, Nigar Kiran, Akhtar Suhail, Khan Azmat Ali, Khan Asifullah

Abstract excerpt

Hepatitis E virus is a primary cause of acute hepatitis worldwide. The present study attempts to assess the genetic variability and evolutionary divergence among HEV genotypes. A vaccine promising capsid-protein coding ORF-2 gene sequences of HEV was evaluated using phylogenetics, model-based population genetic methods and principal component analysis. The analyses unveiled nine distinct clusters as...

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PMID: 38804127
DOI: 10.1111/jvh.13959

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