Characterization of amplicons in neuroblastoma: high-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes.

doi:10.1002/gcc.20583

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Article

Characterization of amplicons in neuroblastoma: high-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes.

Genes, chromosomes & cancer - 1 Oct 2008

Fix Anne, Lucchesi Carlo, Ribeiro Agnès, Lequin Delphine, Pierron Gaëlle, Schleiermacher Gudrun, Delattre Olivier, Janoueix-Lerosey Isabelle

Abstract excerpt

Somatically acquired chromosomal imbalances are a key feature of neuroblastoma, a heterogeneous pediatric solid tumor. Among these alterations, genomic amplification targeting the MYCN oncogene and observed in about 25-30% of the cases, strongly correlates with advanced stage and poor outcome. In this work, we have used BAC and SNP arrays as well as gene expression arrays to characterize amplifications in...

Topics

Child
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Artificial, Bacterial
Chromosomes, Human
DNA, Neoplasm
Gene Amplification
Gene Expression Profiling
Humans
In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

N-Myc Proto-Oncogene Protein

Neuroblastoma

Nuclear Proteins

Oligonucleotide Array Sequence Analysis

Oncogene Proteins

Polymorphism, Single Nucleotide

RNA, Messenger

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 18553563
DOI: 10.1002/gcc.20583

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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