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Article

Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study

1 May 2018

Abstract excerpt

BACKGROUND: In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still unsolved issues. METHODS: The SIOPEN Biology group analysed 99 hetMNA NBs focussing on the...

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PMID: 29755120
DOI: 10.1038/s41416-018-0098-6

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