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Article

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2010

Carén Helena, Kryh Hanna, Nethander Maria, Sjöberg Rose-Marie, Träger Catarina, Nilsson Staffan, Abrahamsson Jonas, Kogner Per, Martinsson Tommy

Abstract excerpt

Analysis of chromosomal aberrations is used to determine the prognosis of neuroblastomas (NBs) and to aid treatment decisions. MYCN amplification (MNA) alone is an incomplete poor prognostic factor, and chromosome 11q status has recently been included in risk classification. We analyzed 165 NB tumors using high-density SNP microarrays and specifically compared the high-risk groups defined by MNA (n = 37) and...

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Share to Chromosomal Instability
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 20145112
DOI: 10.1073/pnas.0910684107
PMCID: PMC2840092

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset.PMID 20145112Read ↗

Identification of a novel recurrent 1q42.2‐1qter deletion in high risk <i>MYCN</i> single copy 11q deleted neuroblastomasSemantic proximity Read ↗

Chromosome Imbalances in Neuroblastoma—Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the FutureSemantic proximity Read ↗

Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progressionSemantic proximity Read ↗

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients.Semantic proximity Read ↗

Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.Semantic proximity Read ↗

Deletion of 11q23 is a frequent event in the evolution of MYCN single-copy high-risk neuroblastomas.Semantic proximity Read ↗

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High-Resolution Analysis of Chromosomal Breakpoints and Genomic Instability Identifies PTPRD as a Candidate Tumor Suppressor Gene in NeuroblastomaSemantic proximity Read ↗

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Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patientsSemantic proximity Read ↗

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