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Article

Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2014

Jia Yujiao, Peng Leiwen, Rao Qing, Xing Haiyan, Huai Lei, Yu Pei, Chen Yirui, Wang Cuicui, Wang Min, Mi Yingchang, Wang Jianxiang

Abstract excerpt

iASPP is a member of the apoptosis-stimulating proteins of p53 (ASPP) family and negatively regulates the apoptotic function of p53. In a hematopoietic system, overexpression of iASPP results in blockage of apoptosis, which may play a role in regulating hematopoietic stem cell (HSC) numbers. To address this, we first analyzed the expression of iASPP in patients with acute leukemia (AL) and found it was highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24668753
DOI: 10.1096/fj.13-244632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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