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Structure Elucidation and Activity of Kolossin A, the D ‐/ L ‐Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

26 Jun 2015

Abstract excerpt

The largest continuous bacterial nonribosomal peptide synthetase discovered so far is described. It consists of 15 consecutive modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium Photorhabdus luminescens. The identification of its cryptic biosynthesis product was achieved by using a combination of genome analysis, promoter exchange, isotopic labeling experiments, and...

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PMID: 26118790
DOI: 10.1002/anie.201502835

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