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Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220

2025-10-31

Abstract excerpt

Actinobacteria are a rich source of bioactive compounds and unique biosynthetic chemistry. Micromonospora echinospora subsp. challisensis NRRL 12255 produces the aromatic polyketide TLN-05220, which exhibits nanomolar activity against antibiotic-resistant human pathogens including vancomycin-resistant Enterococcus faecalis and methicillin-resistant Staphylococcus aureus . The pentangular polyphenol core of TLN...

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Literature Corpus work
5aa1cc1c-253c-5075-abce-8033c11e8373
DOI
10.1101/2025.10.30.685158
Open publication

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Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220DOI 10.1101/2025.10.30.685158
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