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Article

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria.

ACS chemical biology - 15 May 2020

Bratovanov Evgeni V, Ishida Keishi, Heinze Beatrix, Pidot Sacha J, Stinear Timothy P, Hegemann Julian D, Marahiel Mohamed A, Hertweck Christian

Abstract excerpt

Genome mining identified the fungal-bacterial endosymbiosis Rhizopus microsporus-Mycetohabitans (previously Burkholderia) rhizoxinica as a rich source of novel natural products. However, most of the predicted compounds have remained cryptic. In this study, we employed heterologous expression to isolate and characterize three ribosomally synthesized and post-translationally modified peptides with lariat topology...

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Identifiers

PMID: 31800204
DOI: 10.1021/acschembio.9b00805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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