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Article

A mass spectrometry-guided genome mining approach for natural product peptidogenomics.

Nature chemical biology - 9 Oct 2011

Kersten Roland D, Yang Yu-Liang, Xu Yuquan, Cimermancic Peter, Nam Sang-Jip, Fenical William, Fischbach Michael A, Moore Bradley S, Dorrestein Pieter C

Abstract excerpt

Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes. To harvest this large and diverse resource of bioactive molecules, we introduce here natural product peptidogenomics (NPP), a new MS-guided genome-mining method that connects the chemotypes of peptide natural products to their biosynthetic gene...

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Identifiers

PMID: 21983601
DOI: 10.1038/nchembio.684
PMCID: PMC3258187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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