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Article

Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach.

MicrobiologyOpen - 1 Apr 2016

Uytterhoeven Birgit, Appermans Kenny, Song Lijiang, Masschelein Joleen, Lathouwers Thomas, Michiels Chris W, Lavigne Rob

Abstract excerpt

Kalimantacin is an antimicrobial compound with strong antistaphylococcal activity that is produced by a hybrid trans-acyltransferase polyketide synthase/nonribosomal peptide synthetase system in Pseudomonas fluorescens BCCM_ID9359. We here present a systematic analysis of the substrate specificity of the glycine-incorporating adenylation domain from the kalimantacin biosynthetic assembly line by a targeted...

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Identifiers

PMID: 26666990
DOI: 10.1002/mbo3.326
PMCID: PMC4831472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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