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Article

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.

Journal of molecular and cellular cardiology - 1 Jan 2009

Greenberg Michael J, Watt James D, Jones Michelle, Kazmierczak Katarzyna, Szczesna-Cordary Danuta, Moore Jeffrey R

Abstract excerpt

The myosin regulatory light chain (RLC) wraps around the alpha-helical neck region of myosin. This neck region has been proposed to act as a lever arm, amplifying small conformational changes in the myosin head to generate motion. The RLC serves an important structural role, supporting the myosin neck region and a modulatory role, tuning the kinetics of the actin myosin interaction. Given the importance of the...

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Identifiers

PMID: 18929571
DOI: 10.1016/j.yjmcc.2008.09.126
PMCID: PMC2675789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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