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Article

Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin.

The Journal of general physiology - 5 Jul 2021

Rasicci David V, Kirkland Orville, Moonschi Faruk H, Wood Neil B, Szczesna-Cordary Danuta, Previs Michael J, Wenk Jonathan F, Campbell Kenneth S, Yengo Christopher M

Abstract excerpt

Mutations in the cardiac myosin regulatory light chain (RLC, MYL2 gene) are known to cause inherited cardiomyopathies with variable phenotypes. In this study, we investigated the impact of a mutation in the RLC (K104E) that is associated with hypertrophic cardiomyopathy (HCM). Previously in a mouse model of K104E, older animals were found to develop cardiac hypertrophy, fibrosis, and diastolic dysfunction,...

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Identifiers

PMID: 33891674
DOI: 10.1085/jgp.202012811
PMCID: PMC8077168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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