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Article

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.

Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2010

Greenberg Michael J, Kazmierczak Katarzyna, Szczesna-Cordary Danuta, Moore Jeffrey R

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in sarcomeric proteins including the myosin regulatory light chain (RLC). Two such FHC mutations, R58Q and N47K, located near the cationic binding site of the RLC, have been identified from population studies. To examine the molecular basis for the observed phenotypes, we exchanged endogenous RLC from native porcine cardiac myosin with recombinant...

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Share to Adenosine Triphosphate
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic, Familial

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Share to Myocardial Contraction

Share to Myosin Light Chains

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Source

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Identifiers

PMID: 20855589
DOI: 10.1073/pnas.1009619107
PMCID: PMC2951453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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