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Magnetic resonance spectroscopy of paragangliomas: new insights into in vivo metabolomics

25 Jun 2015

Abstract excerpt

Paragangliomas (PGLs) can be associated with mutations in genes of the tricarboxylic acid (TCA) cycle. Succinate dehydrogenase (SDHx) mutations are the prime examples of genetically determined TCA cycle defects with accumulation of succinate. Succinate, which acts as an oncometabolite, can be detected by ex vivo metabolomics approaches. The aim of this study was to evaluate the potential role of proton magnetic...

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PMID: 26115958
DOI: 10.1530/erc-15-0246

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