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Mitochondrial Dysfunction in Parkinson’s Disease

23 Jun 2015

Abstract excerpt

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective mitochondrial function and increased oxidative stress (OS) have been demonstrated as having an important role in PD pathogenesis, although the underlying mechanism is not clear. The etiopathogenesis of sporadic PD is complex with variable...

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PMID: 26113789
DOI: 10.5607/en.2015.24.2.103

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