Article
Mitochondrial dysfunction and oxidative stress in Parkinson's disease.
Progress in neurobiology - 1 Jan 2000
Subramaniam Sudhakar Raja, Chesselet Marie-Francoise
Abstract excerpt
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease thus providing new opportunities to study the pathology of the illness. Studies in humans and...
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