Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The pathological hallmarks of PD include loss of dopaminergic neurons and the presence of Lewy bodies. Mitochondrial dysfunction and oxidative stress are thought to play a pivotal role in both sporadic and familial forms of the disease. In this review we focus...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments
• Share to Pluripotent Stem Cells Research