Article
Evaluation of Hybridization Capture Versus Amplicon-Based Methods for Whole-Exome Sequencing.
Human mutation - 1 Sept 2015
Samorodnitsky Eric, Jewell Benjamin M, Hagopian Raffi, Miya Jharna, Wing Michele R, Lyon Ezra, Damodaran Senthilkumar, Bhatt Darshna, Reeser Julie W, Datta Jharna, Roychowdhury Sameek
Abstract excerpt
Next-generation sequencing has aided characterization of genomic variation. While whole-genome sequencing may capture all possible mutations, whole-exome sequencing remains cost-effective and captures most phenotype-altering mutations. Initial strategies for exome enrichment utilized a hybridization-based capture approach. Recently, amplicon-based methods were designed to simplify preparation and utilize smaller...
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