Article
Comprehensive comparison of three commercial human whole-exome capture platforms.
Genome biology - 28 Sept 2011
Asan, Xu Yu, Jiang Hui, Tyler-Smith Chris, Xue Yali, Jiang Tao, Wang Jiawei, Wu Mingzhi, Liu Xiao, Tian Geng, Wang Jun, Wang Jian, Yang Huangming, Zhang Xiuqing
Abstract excerpt
BACKGROUND: Exome sequencing, which allows the global analysis of protein coding sequences in the human genome, has become an effective and affordable approach to detecting causative genetic mutations in diseases. Currently, there are several commercial human exome capture platforms; however, the relative performances of these have not been characterized sufficiently to know which is best for a particular study....
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