Article
Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review.
Haematologica - 1 Jun 2018
Autore Francesco, Strati Paolo, Laurenti Luca, Ferrajoli Alessandra
Abstract excerpt
Chronic lymphocytic leukemia is an extremely heterogeneous disease and prognostic factors such as chromosomal abnormalities are important predictors of time to first treatment and survival. Trisomy 12 is the second most frequent aberration detected by fluorescence in situ hybridization at the time of diagnosis (10-25%), and it confers an intermediate prognostic risk, with a median time to first treatment of 33...
Topics
- Biomarkers
- Bone Marrow
- Chromosome Aberrations
- Chromosomes, Human, Pair 12
- Combined Modality Therapy
- Genetic Association Studies
- Humans
- Immunoglobulin Heavy Chains
- Immunophenotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Pancytopenia
- Phenotype
- Prognosis
- Receptors, Antigen, B-Cell