Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights from GWAS: emerging landscape of mechanisms underlying complex trait disease.

BMC genomics - 1 Jan 2015

Pal Lipika R, Yu Chen-Hsin, Mount Stephen M, Moult John

Abstract excerpt

BACKGROUND: There are now over 2000 loci in the human genome where genome wide association studies (GWAS) have found one or more SNPs to be associated with altered risk of a complex trait disease. At each of these loci, there must be some molecular level mechanism relevant to the disease. What are these mechanisms and how do they contribute to disease? RESULTS: Here we consider the roles of three primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression
Share to Genome-Wide Association Study
Share to Metabolic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Protein Isoforms

Share to Quantitative Trait Loci

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 26110739
DOI: 10.1186/1471-2164-16-S8-S4
PMCID: PMC4480957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights from GWAS: emerging landscape of mechanisms underlying complex trait disease.PMID 26110739Read ↗

Genetic study of complex diseases in the post-GWAS era.Semantic proximity Read ↗

Towards a complete resolution of the genetic architecture of disease.Semantic proximity Read ↗

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies.Semantic proximity Read ↗

An evolving understanding of multiple causal variants underlying genetic association signals.Semantic proximity Read ↗

Molecular genetic studies of complex phenotypes.Semantic proximity Read ↗

Beyond GWAS: from simple associations to functional insights.Semantic proximity Read ↗

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.Semantic proximity Read ↗

Do genome-wide association scans have potential for translation?Semantic proximity Read ↗

From genetic association to molecular mechanism.Semantic proximity Read ↗

Genome-wide association studies: potential next steps on a genetic journey.Semantic proximity Read ↗

Progress and promise of genome-wide association studies for human complex trait genetics.Semantic proximity Read ↗

A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.