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Genetic study of complex diseases in the post-GWAS era.

Journal of genetics and genomics = Yi chuan xue bao - 20 Mar 2015

Huang Qingyang

Abstract excerpt

Genome-wide association studies (GWASs) have identified thousands of genes and genetic variants (mainly SNPs) that contribute to complex diseases in humans. Functional characterization and mechanistic elucidation of these SNPs and genes action are the next major challenge. It has been well established that SNPs altering the amino acids of protein-coding genes can drastically impact protein function, and play an...

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DNA Methylation
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Polymorphism, Single Nucleotide

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PMID: 25819085
DOI: 10.1016/j.jgg.2015.02.001

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