Article
Both the nature of KIR3DL1 alleles and the KIR3DL1/S1 allele combination affect the KIR3DL1 NK-cell repertoire in the French population.
European journal of immunology - 1 Apr 2013
Gagne Katia, Willem Catherine, Legrand Nolwenn, Djaoud Zakia, David Gaëlle, Rettman Pauline, Bressollette-Bodin Céline, Senitzer David, Esbelin Julie, Cesbron-Gautier Anne, Schneider Thierry, Retière Christelle
Abstract excerpt
NK-cell functions are regulated by many activating and inhibitory receptors including KIR3DL1. Extensive allelic polymorphism and variability in expression can directly alter NK-cell phenotype and functions. Here we investigated the KIR3DL1(+) NK-cell repertoire, taking into account the allelic KIR3DL1/S1 polymorphism, KIR3DL1 phenotype, and function. All 109 studied individuals possessed at least one KIR3DL1...
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