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A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation

24 Jun 2015

Abstract excerpt

Recent progress of genetic studies has dramatically unveiled pathogenesis of acute myeloid leukemia (AML). However, overall survival of AML still remains unsatisfactory, and development of novel therapeutics is required. CCAAT/enhancer binding protein α (C/EBPα) is one of the crucial transcription factors that induce granulocytic differentiation, and its activity is perturbed in human myeloid leukemias. As its...

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PMID: 26109609
DOI: 10.1177/1087057115592220

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