Article

Identification of novel natural product inhibitors of BRD4 using high throughput virtual screening and MD simulation

2022-11-27

Abstract excerpt

Bromodomains are evolutionarily conserved structural motifs that recognize acetylated lysine residues on histone tails. They play a crucial role in shaping chromatin architecture and regulating gene expression in various biological processes. Mutations in bromodomains containing proteins leads to multiple human diseases, which makes them attractive target for therapeutic intervention. Extensive studies have been d...

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Literature Corpus work: 5ec4a384-fa98-5633-8c24-8a75cf990ca9
DOI: 10.1101/2022.11.25.517921

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