Article
Combination of an Oxindole Derivative with (-)-β-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells.
Molecules (Basel, Switzerland) - 6 Jul 2023
Alanazi Jowaher, Bender Onur, Dogan Rumeysa, Malik Jonaid Ahmad, Atalay Arzu, Ali Taha F S, Beshr Eman A M, Shawky Ahmed M, Aly Omar M, Alqahtani Yasir Nasser H, Anwar Sirajudheen
Abstract excerpt
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies less responsive. Therefore, there is a need to find new lead molecules that can specifically target mutated FLT3 to block growth factor signaling and inhibit AML cell...
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