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A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells <i>in vitro</i> and shows anti-tumour effects <i>in vivo</i>

2020-12-18

Abstract excerpt

Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider efficacy, we developed a phenotypic high-throughput screen with a range of genetically diverse cell lines. From the resulting hits, one chemical scaffold was optimised in te...

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Literature Corpus work
9b5b60bb-473b-5836-826a-82e0c2ddd506
DOI
10.1101/2020.12.18.423389
Open publication

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A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells <i>in vitro</i> and shows anti-tumour effects <i>in vivo</i>DOI 10.1101/2020.12.18.423389
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