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Article

Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells.

Haematologica - 1 Oct 2021

Hultmark Simon, Baudet Aurélie, Schmiderer Ludwig, Prabhala Pavan, Palma-Tortosa Sara, Sandén Carl, Fioretos Thoas, Sasidharan Rajkumar, Larsson Christer, Lehmann Sören, Juliusson Gunnar, Ek Fredrik, Magnusson Mattias

Abstract excerpt

Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. However, recent studies have shown that the mutational complexity of acute myeloid leukemia (AML) precludes the translation of molecular targeting into clinical success. Here, as a complement to genetic...

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Identifiers

PMID: 32855276
DOI: 10.3324/haematol.2020.249177
PMCID: PMC8485661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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