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Article

A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo.

Journal of medicinal chemistry - 11 Nov 2021

Josa-Culleré Laia, Madden Katrina S, Cogswell Thomas J, Jackson Thomas R, Carter Tom S, Zhang Douzi, Trevitt Graham, Davies Stephen G, Vyas Paresh, Wynne Graham M, Milne Thomas A, Russell Angela J

Abstract excerpt

Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider efficacy, we developed a phenotypic high-throughput screen with a range of genetically diverse cell lines. From the resulting hits, one chemical scaffold was optimized in...

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Share to Cell Survival
Share to Drug Screening Assays, Antitumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Molecular Structure

Share to Neoplasms, Experimental

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Source

Identifiers

PMID: 34672555
DOI: 10.1021/acs.jmedchem.1c00574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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