Article
Role of biomechanical forces in stem cell vascular lineage differentiation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2014
Potter Claire M F, Lao Ka Hou, Zeng Lingfang, Xu Qingbo
Abstract excerpt
Mechanical forces have long been known to play a role in the maintenance of vascular homeostasis in the mature animal and in developmental regulation in the fetus. More recently, it has been shown that stem cells play a role in vascular repair and remodeling in response to biomechanical stress. Laminar shear stress can directly activate growth factor receptors on stem/progenitor cells, initiating signaling...
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