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Article

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2005

Iizuka Takashi, Ishii Yukio, Itoh Ken, Kiwamoto Takumi, Kimura Toru, Matsuno Yosuke, Morishima Yuko, Hegab Ahmed E, Homma Shinsuke, Nomura Akihiro, Sakamoto Tohru, Shimura Masako, Yoshida Aruto, Yamamoto Masayuki, Sekizawa Kiyohisa

Abstract excerpt

Inflammation, protease/anti-protease imbalance and oxidative stress play important roles in the pathogenesis of emphysema. Nrf2 counteracts oxidative tissue damage and inflammation through transcriptional activation via the anti-oxidant responsive element (ARE). To clarify the protective role of Nrf2 in the development of emphysema, the susceptibility of Nrf2-knockout mice to cigarette smoke (CS)-induced...

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Share to Bronchoalveolar Lavage Fluid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-E2-Related Factor 2

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Share to Proteinase Inhibitory Proteins, Secretory

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Source

Identifiers

PMID: 16324149
DOI: 10.1111/j.1365-2443.2005.00905.x

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SLPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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