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Article

Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis.

Gastroenterology - 1 Oct 2008

Marrache Frederic, Tu Shui Ping, Bhagat Govind, Pendyala Swaroop, Osterreicher Christoph H, Gordon Shanisha, Ramanathan Vigneshwaran, Penz-Osterreicher Melitta, Betz Kelly S, Song Zhigang, Wang Timothy C

Abstract excerpt

BACKGROUND & AIMS: Chronic pancreatitis is a significant cause of morbidity and a known risk factor for pancreatic adenocarcinoma. Interleukin-1beta is a proinflammatory cytokine involved in pancreatic inflammation. We sought to determine whether targeted overexpression of interleukin-1beta in the pancreas could elicit localized inflammatory responses and chronic pancreatitis. METHODS: We created a transgenic...

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Identifiers

PMID: 18789941
DOI: 10.1053/j.gastro.2008.06.078
PMCID: PMC2707078

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Source receipt: pubmed, retrieved 7 Sept 2026.

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