Article
Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis.
Gastroenterology - 1 Oct 2008
Marrache Frederic, Tu Shui Ping, Bhagat Govind, Pendyala Swaroop, Osterreicher Christoph H, Gordon Shanisha, Ramanathan Vigneshwaran, Penz-Osterreicher Melitta, Betz Kelly S, Song Zhigang, Wang Timothy C
Abstract excerpt
BACKGROUND & AIMS: Chronic pancreatitis is a significant cause of morbidity and a known risk factor for pancreatic adenocarcinoma. Interleukin-1beta is a proinflammatory cytokine involved in pancreatic inflammation. We sought to determine whether targeted overexpression of interleukin-1beta in the pancreas could elicit localized inflammatory responses and chronic pancreatitis. METHODS: We created a transgenic...
Topics
- Animals
- Disease Models, Animal
- Female
- Fibrosis
- Gene Expression
- Humans
- Interleukin-1beta
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Pancreas
- Pancreatic Elastase