Article
Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy.
American journal of respiratory and critical care medicine - 1 May 2011
Nakanishi Kaori, Takeda Yoshito, Tetsumoto Satoshi, Iwasaki Takeo, Tsujino Kazuyuki, Kuhara Hanako, Jin Yingji, Nagatomo Izumi, Kida Hiroshi, Goya Sho, Kijima Takashi, Maeda Norikazu, Funahashi Tohru, Shimomura Iichiro, Tachibana Isao, Kawase Ichiro
Abstract excerpt
RATIONALE: Chronic obstructive pulmonary disease is frequently complicated with comorbidities, such as cardiovascular disease, osteoporosis, and body weight loss, but the causal link remains unclear. OBJECTIVES: To investigate the role of adiponectin in the pathogenesis of chronic obstructive pulmonary disease and its potential use in therapy. METHODS: Adiponectin localization and dynamics in the lung were...
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