Article
Functional characterization of a porcine emphysema model.
Lung - 1 Dec 2013
Bruun Camilla Sichlau, Jensen Louise Kruse, Leifsson Páll Skuli, Nielsen Jens, Cirera Susanna, Jørgensen Claus Bøttcher, Jensen Henrik Elvang, Fredholm Merete
Abstract excerpt
BACKGROUND: Lung emphysema is a central feature of chronic obstructive pulmonary disease (COPD), a frequent human disease worldwide. Cigarette smoking is the major cause of COPD, but genetic predisposition seems to be an important factor. Mutations in surfactant protein genes have been linked to COPD phenotypes in humans. Also, the catalytic activities of metalloproteinases (MMPs) are central in the pathogenesis...
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