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Article

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

29 Jan 2016

Abstract excerpt

The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks (SSBs). These breaks remain unrepaired because of a decrease in PARP1 expression and activity. This leads to the formation...

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PMID: 26822533
DOI: 10.1038/ncomms10399

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