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Article

Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.

Antimicrobial agents and chemotherapy - 1 Dec 2011

Feuerriegel Silke, Köser Claudio U, Baù Davide, Rüsch-Gerdes Sabine, Summers David K, Archer John A C, Marti-Renom Marc A, Niemann Stefan

Abstract excerpt

PA-824 is a promising drug candidate for the treatment of tuberculosis (TB). It is in phase II clinical trials as part of the first newly designed regimen containing multiple novel antituberculosis drugs (PA-824 in combination with moxifloxacin and pyrazinamide). However, given that the genes involved in resistance against PA-824 are not fully conserved in the Mycobacterium tuberculosis complex (MTBC), this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21930879
DOI: 10.1128/AAC.05500-11
PMCID: PMC3232757

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Source receipt: pubmed, retrieved 7 Sept 2026.

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