Loss-of-function variants in ATM confer risk of gastric cancer.

doi:10.1038/ng.3342

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Article

Loss-of-function variants in ATM confer risk of gastric cancer.

Nature genetics - 1 Aug 2015

Helgason Hannes, Rafnar Thorunn, Olafsdottir Halla S, Jonasson Jon G, Sigurdsson Asgeir, Stacey Simon N, Jonasdottir Adalbjorg, Tryggvadottir Laufey, Alexiusdottir Kristin, Haraldsson Asgeir, le Roux Louise, Gudmundsson Julius, Johannsdottir Hrefna, Oddsson Asmundur, Gylfason Arnaldur, Magnusson Olafur T, Masson Gisli, Jonsson Thorvaldur, Skuladottir Halla, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Sulem Patrick, Stefansson Kari

Abstract excerpt

Gastric cancer is a serious health problem worldwide, with particularly high prevalence in eastern Asia. Genome-wide association studies (GWAS) in Asian populations have identified several loci that associate with gastric cancer risk. Here we report a GWAS of gastric cancer in a European population, using information on 2,500 population-based gastric cancer cases and 205,652 controls. We found a new gastric...

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Identifiers

PMID: 26098866
DOI: 10.1038/ng.3342

Genes

ATM
MUC1
PRKAA1
MAF
PSCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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