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Article

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2021

Hall Michael J, Bernhisel Ryan, Hughes Elisha, Larson Katie, Rosenthal Eric T, Singh Nanda A, Lancaster Johnathan M, Kurian Allison W

Abstract excerpt

Pathogenic variants (PVs) in ATM are relatively common, but the scope and magnitude of risk remains uncertain. This study aimed to estimate ATM PV cancer risks independent of family cancer history. This analysis included patients referred for hereditary cancer testing with a multi-gene panel (N = 627,742). Cancer risks for ATM PV carriers (N = 4,607) were adjusted for family history using multivariable logistic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Neoplastic Syndromes, Hereditary

Source

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Identifiers

PMID: 33509806
DOI: 10.1158/1940-6207.CAPR-20-0448
PMCID: PMC8026745

Genes

ATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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