Article
Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.
Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2021
Hall Michael J, Bernhisel Ryan, Hughes Elisha, Larson Katie, Rosenthal Eric T, Singh Nanda A, Lancaster Johnathan M, Kurian Allison W
Abstract excerpt
Pathogenic variants (PVs) in ATM are relatively common, but the scope and magnitude of risk remains uncertain. This study aimed to estimate ATM PV cancer risks independent of family cancer history. This analysis included patients referred for hereditary cancer testing with a multi-gene panel (N =...
Topics
- Adult
- Ataxia Telangiectasia Mutated Proteins
- Biomarkers, Tumor
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Neoplastic Syndromes, Hereditary