Article
Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching.
The American journal of pathology - 1 Feb 2003
Chambers Rachel C, Leoni Patricia, Kaminski Naftali, Laurent Geoffrey J, Heller Renu A
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) plays a central role in promoting extracellular matrix protein deposition by promoting the transformation of fibroblasts to myofibroblasts. To gain new insights into the transcriptional programs involved, we profiled human fetal lung fibroblast global gene expression in response to TGF-beta1 up to 24 hours using oligonucleotide microarrays. In this report, we present...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.