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Article

Roles of transforming growth factor‐β1 and OB‐cadherin in porcine cardiac valve myofibroblast differentiation

9 Jul 2014

Abstract excerpt

Calcific aortic stenosis is a common disease, and some of its early causes are the activation and differentiation of resident fibroblasts to myofibroblasts in response to transforming growth factor β1 (TGF-β1). The aim of this study was to understand how TGF-β1 and its downstream effector, OB-cadherin [cadherin 11 (CDH11)], regulate porcine myofibroblast phenotypes. Based on whole-genome microarrays, 95 and 107...

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PMID: 25008089
DOI: 10.1096/fj.14-254623

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