Article

Elucidating the Cellular Mechanism for E2-induced Dermal Fibrosis

2021-02-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Both TGFb and estradiol (E2), a form of estrogen, are pro-fibrotic in the skin. In the connective tissue disease, systemic sclerosis (SSc), both TGFb and E2 are likely pathogenic. Yet, the regulation of TGFb in E2-induced dermal fibrosis remains ill-defined. Elucidating those regulatory mechanisms will improve the understanding of fibrotic disease pathogenesis a...

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Literature Corpus work: 63ce375d-7c24-5d71-9c83-0f54793d8197
DOI: 10.21203/rs.3.rs-103581/v2

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