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Very early-onset inflammatory bowel disease: gaining insight through focused discovery.

Inflammatory bowel diseases - 1 May 2015

Moran Christopher J, Klein Christoph, Muise Aleixo M, Snapper Scott B

Abstract excerpt

The pathogenesis of pediatric inflammatory bowel disease (IBD) is only partially understood. Strong evidence implicates a strong genetic component including high monozygotic twin concordance and familial disease phenotype concordance rates. Genome-wide association studies have identified associations between >160 genetic loci and the risk for developing IBD. The roles of implicated genes are largely...

Topics

Age of Onset
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Inflammatory Bowel Diseases
Phenotype
Prognosis
Translational Research, Biomedical

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Identifiers

PMID: 25895007
DOI: 10.1097/MIB.0000000000000329
PMCID: PMC6165626

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