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The DNA sensor AIM2 mediates psoriasiform inflammation by inducing type 3 immunity

1 Oct 2024

Abstract excerpt

Psoriasis is a chronic and recurrent inflammatory skin disease characterized by abnormal proliferation and differentiation of keratinocytes and activation of immune cells. However, the molecular driver that triggers this immune response in psoriatic skin remains unclear. The inflammation-related gene absent in melanoma 2 (AIM2) was identified as a susceptibility gene/locus associated with psoriasis. In this...

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PMID: 39352743
DOI: 10.1172/jci.insight.171894

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