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Article

Powerful cocktail methods for detecting genome-wide gene-environment interaction.

Genetic epidemiology - 1 Apr 2012

Hsu Li, Jiao Shuo, Dai James Y, Hutter Carolyn, Peters Ulrike, Kooperberg Charles

Abstract excerpt

Identifying gene and environment interaction (G × E) can provide insights into biological networks of complex diseases, identify novel genes that act synergistically with environmental factors, and inform risk prediction. However, despite the fact that hundreds of novel disease-associated loci have been identified from genome-wide association studies (GWAS), few G × Es have been discovered. One reason is that...

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PMID: 22714933
DOI: 10.1002/gepi.21610
PMCID: PMC3654520

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