Article
Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2020
Ohishi Hiroaki, Au Yeung Wan Kin, Unoki Motoko, Ichiyanagi Kenji, Fukuda Kei, Maenohara Shoji, Shirane Kenjiro, Chiba Hatsune, Sado Takashi, Sasaki Hiroyuki
Abstract excerpt
Monoallelic gene expression occurs in various mammalian cells and can be regulated genetically, epigenetically and/or stochastically. We identified 145 monoallelically expressed genes (MoEGs), including seven known imprinted genes, in mouse embryonic stem cells (ESCs) derived from reciprocal F1 hybrid blastocysts and cultured in 2i/LIF. As all MoEGs except for the imprinted genes were expressed in a...
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